Gescuk B, Wu A J, Whitcher J P, Daniels T E, Lund S, Fye K, Davis J C
Clinical Trials Center, Division of Rheumatology, University of California, San Francisco, 533 Parnassus Avenue Box 0633 Room U383, San Francisco, CA 94143-0633, USA.
Ann Rheum Dis. 2005 Sep;64(9):1326-30. doi: 10.1136/ard.2004.031393. Epub 2005 Feb 11.
Retroviral infection has been implicated in the pathogenesis of primary Sjögren's syndrome.
To examine the efficacy of the reverse transcriptase inhibitor lamivudine in patients with this syndrome.
16 patients with primary Sjögren's syndrome were randomised to receive either lamivudine 150 mg twice daily or placebo for three months. Measures of lacrimal and salivary function, including minor salivary gland biopsies, were obtained before and after treatment.
Treatment with lamivudine did not result in significant improvement in the primary outcome measure of unstimulated whole salivary flow or other secondary measures, including minor salivary gland biopsy focus scores.
Lamivudine is not effective in patients with primary Sjögren's syndrome, suggesting either that a retroviral aetiology is not present or that it may be important only in early disease.
逆转录病毒感染与原发性干燥综合征的发病机制有关。
研究逆转录酶抑制剂拉米夫定对该综合征患者的疗效。
16例原发性干燥综合征患者被随机分为两组,分别接受每日两次150毫克拉米夫定或安慰剂治疗,为期三个月。在治疗前后获取泪腺和唾液腺功能指标,包括小唾液腺活检。
拉米夫定治疗并未使非刺激性全唾液流量这一主要结局指标或其他次要指标(包括小唾液腺活检灶性评分)得到显著改善。
拉米夫定对原发性干燥综合征患者无效,这表明要么不存在逆转录病毒病因,要么其可能仅在疾病早期起重要作用。