de Azevedo Bianca Benatti, Bussoloti Filho Ivo
UNIFESP.
Braz J Otorhinolaryngol. 2005 May-Jun;71(3):346-54. doi: 10.1016/S1808-8694(15)31334-3. Epub 2005 Dec 14.
jögren's Syndrome is an autoimmune disease of the exocrine glands, mainly salivary and lachrymal glands. There is no gold standard test for diagnosis. : evaluation of the importance of minor salivary gland biopsy and sialometry, isolated or associated, as methods for classification of Sjögren's Syndrome. : Transversal cohort. : Seventy-two patients that reported dry mouth from January 1997 to September 2003 were investigated and classified, based on the established criteria. Non-stimulated sialometry was performed by the swab technique. Histopathology exams were evaluated for the presence of inflammatory focus. : Non-stimulated sialometry and minor salivary gland biopsy presented different sensitivities for primary Sjögren's Syndrome and for secondary Sjögren's Syndrome. Focal sialadenitis with higher focus score was characteristic of primary Sjögren's Syndrome. Biopsy and sialometry were compared and it was observed that specificity and positive predictive value of biopsy were higher. Comparing biopsy and biopsy associated with sialometry, it was observed that biopsy had higher sensitivity and negative predictive value. Specificity of biopsy associated with sialometry was higher. Comparing sialometry and biopsy associated with sialometry, it was observed that biopsy associated with sialometry presented higher positive predictive value and higher specificity. Sialometry's sensitivity was higher. ialometry and biopsy tests presented different performances in primary Sjögren's Syndrome and secondary Sjögren's Syndrome; the positivity of the association of both tests increases the specificity for Sjögren's Syndrome (95%).
干燥综合征是一种外分泌腺的自身免疫性疾病，主要累及唾液腺和泪腺。目前尚无诊断的金标准。：评估唇腺活检和唾液流量测定单独或联合作为干燥综合征分类方法的重要性。：横向队列研究。：对1997年1月至2003年9月期间报告有口干症状的72例患者进行调查，并根据既定标准进行分类。采用棉签技术进行非刺激性唾液流量测定。评估组织病理学检查中炎症灶的存在情况。：非刺激性唾液流量测定和唇腺活检对原发性干燥综合征和继发性干燥综合征表现出不同的敏感性。原发性干燥综合征的特征是局灶性涎腺炎且灶性评分较高。对活检和唾液流量测定进行比较，发现活检的特异性和阳性预测值更高。将活检与唾液流量测定联合的活检进行比较，发现活检的敏感性和阴性预测值更高。唾液流量测定联合活检的特异性更高。将唾液流量测定与唾液流量测定联合活检进行比较，发现唾液流量测定联合活检的阳性预测值和特异性更高。唾液流量测定的敏感性更高。唾液流量测定和活检在原发性干燥综合征和继发性干燥综合征中表现出不同的性能；两种检查联合阳性可提高干燥综合征的特异性（95%）。
