Nash P, Mease P J, Braun J, van der Heijde D
Rheumatology Research Unit, Nambour Hospital, Sunchine Coast, University of Queensland, Queensland, Australia.
Ann Rheum Dis. 2005 Mar;64 Suppl 2(Suppl 2):ii9-13. doi: 10.1136/ard.2004.033654.
The advent of novel biological therapies for the treatment of rheumatic disease has renewed interest in the seronegative spondyloarthropathies (SpAs). International efforts are redefining disease classification and measures of disease activity, outcome, metrology, and imaging. However, opinion is divided between those who propose that the SpA group represents the same disease with variable expression (the "lumpers") and those who consider these to be separate diseases with shared clinical features (the "splitters"). This review presents the evidence for both approaches.
用于治疗风湿性疾病的新型生物疗法的出现,重新引发了人们对血清阴性脊柱关节病(SpAs)的兴趣。国际上正在重新界定疾病分类以及疾病活动、预后、测量学和影像学的衡量标准。然而,对于SpA组是代表具有不同表现的同一种疾病(“合并派”),还是认为这些是具有共同临床特征的不同疾病(“细分派”),存在意见分歧。本综述展示了这两种方法的证据。