丝裂霉素C注入治疗非小细胞肺癌恶性心包积液
Management of malignant pericardial effusion with instillation of mitomycin C in non-small cell lung cancer.
作者信息
Kaira Kyoichi, Takise Atsushi, Kobayashi Go, Utsugi Mitsuyoshi, Horie Takeo, Mori Takanori, Imai Hisao, Inazawa Masahito, Mori Masatomo
机构信息
Maebashi Red Cross Hospital, Department of Respiratory Medicine, 3-21-36, Asahi-cho, Maebashi, Gunma 377-0014, Japan.
出版信息
Jpn J Clin Oncol. 2005 Feb;35(2):57-60. doi: 10.1093/jjco/hyi019.
BACKGROUND
To evaluate the clinical efficacy and safety of mitomycin C in the local control of malignant pericardial effusion, we carried out a trial of pericardial drainage with local instillation of mitomycin C in eight patients who suffered from cardiac tamponade or symptomatic large pericardial effusion caused by advanced non-small cell lung cancer.
METHODS
After complete removal of the pericardial effusion by an ultrasound-guided inserted catheter, 2 mg of mitomycin C was instilled into the pericardial space via the catheter.
RESULTS
The drainage catheter was successfully removed in all patients. The duration of pericardial drainage ranged from 7 to 14 days (median 10.5 days). Six of the eight patients achieved a complete remission of pericardial effusions without any adverse effects.
CONCLUSION
Intrapericardial instillation of 2 mg of mitomycin C was feasible and demonstrated a promising response against malignant pericardial effusion resulting from non-small cell lung cancer.
背景
为评估丝裂霉素C在局部控制恶性心包积液方面的临床疗效和安全性，我们对8例因晚期非小细胞肺癌导致心脏压塞或有症状的大量心包积液的患者进行了心包穿刺引流并局部注入丝裂霉素C的试验。
方法
在超声引导下经导管完全清除心包积液后，通过导管将2mg丝裂霉素C注入心包腔。
结果
所有患者的引流导管均成功拔除。心包引流持续时间为7至14天（中位时间10.5天）。8例患者中有6例心包积液完全缓解，且无任何不良反应。
结论
心包腔内注入2mg丝裂霉素C是可行的，并且对非小细胞肺癌所致恶性心包积液显示出良好的疗效。
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