Velasco M J, Ortiz V, Ponce J
Servicio de Medicina Digestiva, Hospital Universitari La Fe, Valencia, Spain.
Gastroenterol Hepatol. 2005 Feb;28(2):65-7. doi: 10.1157/13070702.
Resistance to proton pump inhibitors (PPI) in gastroesophageal reflux disease (GERD), which has been described in patients treated with omeprazole, could explain some exceptional cases of treatment failure and the need for surgery. The objective test of resistance to PPI is obtained with 24-hour intragastric pH-metry performed during treatment. A gastric pH of less than 4 for more than 50% of recording time indicates resistance. We present a patient with non-erosive GERD and treatment failure to omeprazole and proven resistance to esomeprazole which, to our knowledge, has only been reported in patients with Barrett's esophagus.
胃食管反流病（GERD）患者对质子泵抑制剂（PPI）产生耐药性的情况已在接受奥美拉唑治疗的患者中有所描述，这可以解释一些治疗失败的特殊病例以及手术需求。对PPI耐药性的客观检测是在治疗期间进行24小时胃内pH值测定。记录时间超过50%时胃内pH值小于4表明存在耐药性。我们报告了一名患有非糜烂性GERD的患者，对奥美拉唑治疗无效且已证实对埃索美拉唑耐药，据我们所知，这种情况仅在巴雷特食管患者中报道过。
