Sakata Shuzo, Komatsu Yusuke, Yamamori Tetsuo
Division of Brain Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 4448585, Japan.
Neurosci Res. 2005 Mar;51(3):309-15. doi: 10.1016/j.neures.2004.11.004. Epub 2004 Dec 23.
To understand global and local design principles of mammalian cerebral cortical networks, we applied network-theoretical approaches to connectivity data from macaque and cat cortical networks. We first confirmed "small-world" properties and searched for the evidence of hierarchical modularity. To elucidate their local design principles, we then compared these cortical networks, based on the significance profile (SP) of network motifs in the real network compared to randomized networks. We found that SPs of different mammalian cortical networks are highly conserved and robust, suggesting constraints of neocortical development and evolution.
为了理解哺乳动物大脑皮层网络的全局和局部设计原则，我们将网络理论方法应用于猕猴和猫皮层网络的连接性数据。我们首先确认了“小世界”特性，并寻找层次模块化的证据。为了阐明它们的局部设计原则，我们随后基于真实网络与随机网络中网络基序的显著性分布（SP）对这些皮层网络进行了比较。我们发现，不同哺乳动物皮层网络的SP高度保守且稳健，这表明新皮层发育和进化受到限制。
