Nouri-Mahdavi Kouros, Caprioli Joseph, Coleman Anne L, Hoffman Douglas, Gaasterland Douglas
Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles, 90095-7004, USA.
Arch Ophthalmol. 2005 Feb;123(2):193-9. doi: 10.1001/archopht.123.2.193.
To investigate pointwise linear regression (PLR) for longitudinal evaluation of visual fields and to compare results with those of the Advanced Glaucoma Intervention Study (AGIS) criteria.
We selected 509 eyes (401 patients) from the AGIS with 3 or more years of follow-up, 7 or more visual field examinations, and an AGIS reference score of 16 or lower. Visual field change at test locations was defined as a change of threshold sensitivity of 1 dB/y or higher and P<or=.01. Several sets of criteria were investigated for defining change of visual field series with PLR.
Progression or improvement of visual field series with PLR and AGIS criteria.
Mean (SD) follow-up time and baseline AGIS score were 7.4 (1.7) years and 7.7 (4.4), respectively. Pairwise agreement between AGIS and various PLR criteria ranged from 52% to 64% with the kappa statistic varying between 0.22 (95% confidence interval, 0.15-0.29) and 0.30 (95% confidence interval, 0.22-0.38). One hundred thirty-eight (27%) and 151 (30%) eyes progressed (85 eyes or 17% detected by both methods) while 72 (14%) and 11 (2%) eyes improved (5 eyes or 1% detected by both methods) based on AGIS and the most rigorous PLR criteria, respectively.
Based on rigorous, clinically relevant criteria, PLR detects progression in a similar proportion of eyes compared with AGIS criteria. Pointwise linear regression may be superior to AGIS methods since it identifies fewer visual field series as improving.
研究逐点线性回归（PLR）用于视野纵向评估的情况，并将结果与高级青光眼干预研究（AGIS）标准的结果进行比较。
我们从AGIS中选取了509只眼（401例患者），这些患者有3年或更长时间的随访、7次或更多次视野检查，且AGIS参考评分在16或更低。测试位点的视野变化定义为阈值敏感度每年变化1 dB或更高且P≤0.01。研究了几组用于定义PLR视野系列变化的标准。
PLR和AGIS标准下视野系列的进展或改善情况。
平均（标准差）随访时间和基线AGIS评分为7.4（1.7）年和7.7（4.4），分别。AGIS与各种PLR标准之间的两两一致性范围为52%至64%，kappa统计量在0.22（95%置信区间，0.15 - 0.29）和0.30（95%置信区间，0.22 - 0.38）之间变化。基于AGIS和最严格的PLR标准，分别有138只眼（27%）和151只眼（30%）进展（两种方法均检测到85只眼或17%），而72只眼（14%）和11只眼（2%）改善（两种方法均检测到5只眼或1%）。
基于严格的、临床相关标准，与AGIS标准相比，PLR在相似比例的眼中检测到进展。逐点线性回归可能优于AGIS方法，因为它将更少的视野系列判定为改善。
