Guo Hongnian, Brewer Judy McKinley, Champhekar Ameya, Harris Ruth B S, Bittman Eric L
Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA 01003, USA.
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3111-6. doi: 10.1073/pnas.0409734102. Epub 2005 Feb 14.
Although dependent on the integrity of a central pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN), endogenous daily (circadian) rhythms are expressed in a wide variety of peripheral organs. The pathways by which the pacemaker controls the periphery are unclear. Here, we used parabiosis between intact and SCN-lesioned mice to show that nonneural (behavioral or bloodborne) signals are adequate to maintain circadian rhythms of clock gene expression in liver and kidney, but not in heart, spleen, or skeletal muscle. These results indicate that the SCN regulates expression of circadian oscillations in different peripheral organs by diverse pathways.
尽管内源性日常（昼夜节律）节律依赖于下丘脑视交叉上核（SCN）中中央起搏器的完整性，但在多种外周器官中都有表达。起搏器控制外周的途径尚不清楚。在这里，我们利用完整小鼠和SCN损伤小鼠之间的联体生活实验表明，非神经（行为或血源性）信号足以维持肝脏和肾脏中生物钟基因表达的昼夜节律，但在心脏、脾脏或骨骼肌中则不然。这些结果表明，SCN通过不同途径调节不同外周器官中昼夜节律振荡的表达。
