Amini-Sereshki L
Adult Health and Illness, University of Pennsylvania, Philadelphia 19104.
Pathobiology. 1992;60(2):113-6. doi: 10.1159/000163708.
The pontine tegmentum of the cat was lesioned by microinjection of a cytotoxin (ibotenic acid) into the brainstem. The sleep-waking cycle of intact cats and cats with the cytotoxic lesions of the pontine tegmentum was studied as a function of ambient temperature. In a cold environment lesioned cats showed a reduction in sleep that was significantly greater than the reduction shown by the intact animals. In a warm environment cats with the tegmental lesions show changes in the sleep-waking cycle similar to intact animals. It is shown that in wakefulness the cytotoxically pontine lesioned cats are more sensitive to cold, but not to heat, than intact animals. The results of these experiments are consistent with the hypothesis that the decreased sleep shown by lesioned animals is due to an alteration in thermoregulation such that the damaged brain interprets ambient temperature to be colder than it is.
通过向脑干微量注射一种细胞毒素（鹅膏蕈氨酸）来损伤猫的脑桥被盖部。研究了完整猫以及脑桥被盖部有细胞毒性损伤的猫的睡眠 - 觉醒周期与环境温度的关系。在寒冷环境中，有损伤的猫的睡眠减少程度明显大于完整动物。在温暖环境中，有被盖部损伤的猫的睡眠 - 觉醒周期变化与完整动物相似。结果表明，在清醒状态下，脑桥有细胞毒性损伤的猫比完整动物对寒冷更敏感，但对热不敏感。这些实验结果与以下假设一致，即有损伤的动物睡眠减少是由于体温调节改变，使得受损的大脑将环境温度解读为比实际温度更冷。
