Saegusa S, Shimizu F, Nagase M, Kasegawa A
Arch Pathol Lab Med. 1979 Aug;103(9):475-8.
We describe tubular antigen-positive immune-complex nephritis in a case of feline renal amyloidosis. Amyloid deposition was observed in mesangial area, and thickening of capillary walls was shown in the majority of the glomeruli. This case was also characterized with typical fluorescent granular depositions of cat IgG and C3 along the glomerular capillary walls as seen in human membranous glomerulonephritis. The fluorescent pattern of tubular antigen was identical with that of IgG and C3. Electron micrograph showed the thickening and irregularity of glomerular basement membranes, fusion of foot processes, and deposits of electron-dense or sometimes translucent materials, mostly in the intramembranous location. The causal sequence of the coincidental deposition of amyloid and immune complexes is discussed.
我们描述了一例猫肾淀粉样变性病例中的肾小管抗原阳性免疫复合物性肾炎。在系膜区观察到淀粉样物质沉积，大多数肾小球显示毛细血管壁增厚。该病例的特征还包括，如人类膜性肾小球肾炎所见，猫IgG和C3沿肾小球毛细血管壁呈典型的荧光颗粒状沉积。肾小管抗原的荧光模式与IgG和C3相同。电子显微镜检查显示肾小球基底膜增厚和不规则，足突融合，以及电子致密或有时半透明物质的沉积，主要位于膜内。文中讨论了淀粉样物质和免疫复合物同时沉积的因果关系。
