猫的医源性金属汞中毒相关的膜性肾小球肾炎和肾病综合征

Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat.

作者信息

Shull R M, Stowe C M, Osborne C A, O'Leary T P, Vernier R L, Hammer R F

出版信息

Vet Hum Toxicol. 1981 Feb;23(1):1-5.

Abstract

The nephrotic syndrome, characterized by nonselective proteinuria, hypoproteinemia, hypoalbuminemia, and ascites, was observed in a 10-month-old male cat. Profound glomerular changes and renal tubular changes appear to have been induced by iatrogenic chronic exposure to metallic mercury originally contained in a rectal thermometer. Large concentrations of mercury were present in the kidneys, liver, spleen, and urine. Evaluation of glomeruli by immunofluorescent microscopy revealed interrupted granular deposition of immuno-globulin G and the third component of complement in glomerular capillary walls and the mesangium. Electron microscopic evaluation of glomeruli revealed diffuse alterations in glomerular basement membranes and visceral epithelial cells. Small electron dense deposits were observed in capillary walls, but they were not characteristic of immune complexes. The mechanism(s) responsible for the mercury induced glomerulonephropathy in this patient could not be determined on the basis of available data.

摘要

一只10个月大的雄性猫出现了以非选择性蛋白尿、低蛋白血症、低白蛋白血症和腹水为特征的肾病综合征。医源性长期接触原本含于直肠体温计中的金属汞似乎诱发了严重的肾小球和肾小管改变。肾脏、肝脏、脾脏和尿液中存在大量汞。免疫荧光显微镜检查肾小球显示，免疫球蛋白G和补体第三成分在肾小球毛细血管壁和系膜中呈间断颗粒状沉积。肾小球的电子显微镜评估显示肾小球基底膜和脏层上皮细胞有弥漫性改变。在毛细血管壁观察到小的电子致密沉积物，但它们并非免疫复合物的特征性表现。根据现有数据无法确定该患者汞诱导的肾小球肾病的发病机制。