Meshikhes A W N
Department of Surgery, Dammam Central Hospital, Dammam, Eastern Province, Saudi Arabia.
Surgeon. 2004 Dec;2(6):335-8, 361. doi: 10.1016/s1479-666x(04)80032-5.
Daflon, a phlebotropic agent, is of proven efficacy in the treatment of various venous disorders. Although it has been tried in the treatment of haemorrhoids, its efficacy in alleviating various haemorrhoidal symptoms has not been assessed properly. The aim of this study was to confirm the efficacy of Daflon in the treatment of haemorrhoidal symptoms.
Two hundred and sixty eight patients presenting with haemorrhoidal symptoms were recruited. This was a multicentre non-randomised observational study with no placebo arm. After establishing the extent of their symptoms and determining the position, size and degree of haemorrhoids by proctoscopy, all patients were started on Daflon, four tablets per day, in two divided doses for four weeks. Patients were seen weekly during the study period and carefully questioned as regard to symptoms, and a proctoscopy was carried out.
There was a statistically significant improvement (p<0.001) in all haemorrhoidal symptoms (pain, heaviness, bleeding, pruritus and anal discharge) and in the proctoscopic appearance of the 'piles,' comparing baseline visit findings with the last visit four weeks after treatment with Daflon.
Daflon has been shown to be effective in alleviating (variable degree) haemorrhoidal symptoms and improving the proctoscopic appearance of haemorrhoids. Therefore, it should be considered initially for patients presenting with haemorrhoidal symptoms. However, prospective randomised trials and longer follow-up are needed to confirm the findings of this study and delineate more precisely the role of Daflon in the management of haemorrhoidal disease
屈黄酮，一种静脉活性药物，已被证实对治疗各种静脉疾病有效。尽管它已被尝试用于治疗痔疮，但其缓解各种痔疮症状的疗效尚未得到恰当评估。本研究的目的是证实屈黄酮治疗痔疮症状的疗效。
招募了268例有痔疮症状的患者。这是一项无安慰剂组的多中心非随机观察性研究。在确定症状程度并通过直肠镜检查确定痔疮的位置、大小和程度后，所有患者开始服用屈黄酮，每日4片，分两次服用，持续4周。在研究期间每周对患者进行检查，并仔细询问症状，同时进行直肠镜检查。
与屈黄酮治疗4周后的最后一次就诊结果相比，在治疗结束时，所有痔疮症状（疼痛、坠胀感、出血、瘙痒和肛门分泌物）以及直肠镜下“痔”的表现均有统计学意义的改善（p<0.001）。
已证明屈黄酮在缓解（不同程度）痔疮症状和改善直肠镜下痔疮表现方面有效。因此，对于有痔疮症状的患者应首先考虑使用。然而，需要进行前瞻性随机试验和更长时间的随访，以证实本研究的结果，并更精确地界定屈黄酮在痔疮疾病管理中的作用。
