Hallaoui Y, El Kohen A, Sefiani S, Benchekroun L, Jazouli N, Kzadri M
CHU Avicenne, Hôpital des Spécialités, Service ORL, Rabat, Maroc.
Rev Laryngol Otol Rhinol (Bord). 2004;125(4):229-32.
Laryngeal neuroendocrine carcinomas are uncommon and not well known tumors. Three histological subtypes, each of them with a different prognosis and treatment, can be identified. We report a case of a large cell laryngeal neuroendocrine carcinoma in 32 old-year boy who presented a right glotto-subglottic tumoral process. The patient was treated by total laryngectomy associated with bilateral functional neck dissection but without postoperative chemotherapy. A disease recurrence occured three months after surgery consisting on a massive involvment of laterocervical and sus clavicular lymph nodes. The authors discussed the clinical features, the histological and immunohistochemical characteristics, the treatment and the prognosis of laryngeal neuroendocrine carcinoma, according to literature. (full article translated in English available on www.ent-review.com).
喉神经内分泌癌是罕见且鲜为人知的肿瘤。可识别出三种组织学亚型,每种亚型的预后和治疗方法都不同。我们报告一例32岁男性的大细胞喉神经内分泌癌病例,该患者表现为右侧声门-声门下肿瘤病变。患者接受了全喉切除术及双侧功能性颈清扫术,但未进行术后化疗。术后三个月疾病复发,表现为颈外侧和锁骨上淋巴结大量受累。作者根据文献讨论了喉神经内分泌癌的临床特征、组织学和免疫组化特征、治疗及预后。(完整文章的英文译文可在www.ent-review.com上获取)