Salvador Villalba I, Martínez Leandro E, Alemany Monraval P, Martorell Cebollada M, Basterra Alegre J
Servicio de Anatomía Patológica, Hospital General Universitario, Valencia.
Acta Otorrinolaringol Esp. 1995 Sep-Oct;46(5):377-80.
We present a case of moderately differentiated neuroendocrine carcinoma of the larynx. These tumors represent 0.6% of all laryngeal carcinomas. Histological diagnosis requires the use of immunohistochemical methods, the tumoral cells presenting positivity for epithelial markers (cytokeratin) and neuroendocrine markers (chromogranin). Clinically, their location is supraglottic and they affect mainly males between the 6th-7th decades of life. The prognosis is better than that of squamous carcinoma or adenocarcinoma. The differential diagnosis must be made with granular cell tumor and paragangliomas.
我们报告一例喉中分化神经内分泌癌。这些肿瘤占所有喉癌的0.6%。组织学诊断需要使用免疫组化方法，肿瘤细胞对上皮标志物（细胞角蛋白）和神经内分泌标志物（嗜铬粒蛋白）呈阳性反应。临床上，它们位于声门上区，主要影响60至70岁之间的男性。其预后优于鳞状细胞癌或腺癌。必须与颗粒细胞瘤和副神经节瘤进行鉴别诊断。
