Chambers M G, Jasani M K, Bitensky L, Chayen J
Unit of Cellular Pharmacology and Toxicology, Robens Institute of Health and Safety, University of Surrey, Guildford, UK.
Int J Exp Pathol. 1992 Apr;73(2):115-23.
Most of the male STR/ORT mice develop osteoarthritis (OA) involving the medial tibial plateau. A peculiarity of two chondroprotective drugs is the presence of a nitrogen atom so that cleavage of the molecule could generate a molecule that might act as an inhibitor of monoamine oxidase (MAO). Direct examination showed abnormal localization of MAO in the potentially osteoarthritic cartilage indicating possible abnormal response to catecholamines. In normal cartilage, the direct effect of excessive concentration of adrenaline caused considerable oedema, as measured by microscopic interferometry. It is therefore suggested that the excess of water found in the matrix of osteoarthritic cartilage may be related to disturbance of the MAO activity.
大多数雄性STR/ORT小鼠会患上涉及内侧胫骨平台的骨关节炎（OA）。两种软骨保护药物的一个特点是含有氮原子，因此分子裂解可能会产生一种可能作为单胺氧化酶（MAO）抑制剂的分子。直接检查显示，MAO在潜在骨关节炎软骨中的定位异常，表明对儿茶酚胺可能有异常反应。在正常软骨中，通过显微镜干涉测量法测得，肾上腺素浓度过高的直接作用会导致相当程度的水肿。因此，有人提出，在骨关节炎软骨基质中发现的水分过多可能与MAO活性紊乱有关。
