Chayen J, Bitensky L, Chambers M G
Department of Medicine, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
Cell Biochem Funct. 1996 Mar;14(1):57-61. doi: 10.1002/cbf.643.
Up to nine out of 10 male STR/ORT mice develop osteoarthritis (OA) of the medial tibial cartilage at an early age. This has now been shown to be related to changes in the activity and distribution of monoamine oxidase which is related to the metabolism of catecholamines. Treatment with diclofenac sodium tended to normalize this activity but there was no significant histological improvement. It was therefore postulated that two influences were involved in the development of OA: a cellular and an extracellular factor. The first was improved by diclofenac sodium; the second, namely oedema of the matrix, was improved by tribenoside. In very preliminary studies, feeding the two drugs simultaneously resulted in 7/9 mice having no sign of OA.
高达十分之九的雄性STR/ORT小鼠在幼年时会患上内侧胫骨软骨骨关节炎（OA）。现已证明，这与单胺氧化酶的活性和分布变化有关，而单胺氧化酶与儿茶酚胺的代谢相关。双氯芬酸钠治疗倾向于使这种活性正常化，但组织学上没有显著改善。因此推测，OA的发展涉及两种影响因素：细胞因素和细胞外因素。第一种因素可通过双氯芬酸钠改善；第二种因素，即基质水肿，可通过曲克芦丁改善。在非常初步的研究中，同时投喂这两种药物，结果显示9只小鼠中有7只没有OA迹象。
