Heiner Anneliese D, Callaghan John J, Brown Thomas D
Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA.
J Biomech. 2005 Apr;38(4):811-8. doi: 10.1016/j.jbiomech.2004.05.005.
The purpose of this study was to determine the apparent modulus changes accompanying a novel procedure for simulating in situ fusion of morselized cancellous bone femoral impaction grafts. An experienced surgeon's habitual intra-operative impaction grafting protocol was first quantified in human cadaver femurs, using a customized impulse force hammer. A corresponding standardized impaction procedure was then defined, and was used to prepare impaction grafts in axisymmetric metallic fixturing designed to replicate the nominal geometry of femoral canal confinement. Impaction graft fusion was simulated by mixing morselized cancellous bone with an amine-based epoxy adhesive before the impaction, then allowing the mixture to fuse after the impaction (J. Biomech. 34 (2001) 811). Force/deflection behavior of the unfused and fused impaction grafts was measured for both the (tapered) proximal and (untapered) distal portions of the grafts. Apparent modulus was then calculated from force/deflection stiffness. The impaction graft fusion simulation increased apparent modulus by an order of magnitude over the unfused state, for mixture parameters appropriate to have the fused graft apparent modulus be comparable to the compressive modulus of intact femoral cancellous bone.
本研究的目的是确定一种模拟松质骨股骨嵌压植骨原位融合的新方法所伴随的表观模量变化。首先，使用定制的冲击力锤在人体尸体股骨中对一位经验丰富的外科医生惯常的术中嵌压植骨方案进行量化。然后定义了相应的标准化嵌压程序，并用于在轴对称金属固定装置中制备嵌压植骨，该固定装置旨在复制股骨髓腔限制的标称几何形状。通过在嵌压前将松质骨碎块与胺基环氧树脂粘合剂混合，然后在嵌压后使混合物融合来模拟嵌压植骨融合（《生物力学杂志》34 (2001) 811）。对未融合和融合的嵌压植骨的（锥形）近端和（非锥形）远端部分测量力/位移行为。然后根据力/位移刚度计算表观模量。对于使融合后的植骨表观模量与完整股骨松质骨的压缩模量相当的混合物参数，嵌压植骨融合模拟使表观模量比未融合状态提高了一个数量级。
