Chan Andrew
Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sci STKE. 2005 Feb 15;2005(271):tr5. doi: 10.1126/stke.2712005tr5.
This Teaching Resource provides lecture notes and slides for a class covering three kinase-mediated signaling pathways and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The focus is three major signaling cascades that are implicated in cell proliferation, survival, and stress response. They are, respectively, the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and Jun N-terminal kinase (JNK) cascades. The aim of this lecture is to review the major players of these intracellular signaling cascades in mammalian cells. In addition, emphasis is placed on understanding the dynamic, rather than linear, nature of signal transduction in determining cellular responses to external stimuli.
本教学资源提供了涵盖三种激酶介导的信号通路课程的讲义和幻灯片，是“细胞信号系统：研究生课程”的一部分。重点是涉及细胞增殖、存活和应激反应的三个主要信号级联反应。它们分别是丝裂原活化蛋白激酶（MAPK）、磷脂酰肌醇3激酶（PI3K）和Jun N端激酶（JNK）级联反应。本次讲座的目的是回顾这些细胞内信号级联反应在哺乳动物细胞中的主要参与者。此外，重点在于理解信号转导在决定细胞对外部刺激的反应时的动态而非线性性质。
