Caplan Avrom
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Sci STKE. 2005 Feb 22;2005(272):tr7. doi: 10.1126/stke.2722005tr7.
This Teaching Resource provides lecture notes and slides for a class covering the structure and function of protein kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the genomics and evolutionary relationships among kinases and then proceeds to describe the structure-function relationships of specific kinases, the molecular mechanisms underlying substrate specificity, and selected issues in regulation of kinase activity.
本教学资源提供了关于蛋白激酶结构与功能课程的讲义和幻灯片,是“细胞信号系统:研究生课程”的一部分。讲座首先讨论了激酶之间的基因组学和进化关系,然后阐述了特定激酶的结构 - 功能关系、底物特异性背后的分子机制以及激酶活性调节的一些选定问题。