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酒精对基因动物模型中枢神经系统基因表达的影响。

Alcohol effects on central nervous system gene expression in genetic animal models.

作者信息

McBride William J, Kerns Robnet T, Rodd Zachary A, Strother Wendy N, Edenberg Howard J, Hashimoto Joel G, Wiren Kristine M, Miles Michael F

机构信息

Indiana University School of Medicine, Indianapolis, Indiana, USA.

出版信息

Alcohol Clin Exp Res. 2005 Feb;29(2):167-75. doi: 10.1097/01.alc.0000153539.40955.42.

DOI:10.1097/01.alc.0000153539.40955.42
PMID:15714040
Abstract

This article summarizes the proceedings of a symposium presented at the 2004 annual meeting of the Research Society on Alcoholism in Vancouver, British Columbia, Canada. The organizers and chairs were William J. McBride and Michael F. Miles. The presentations were (1) Molecular Triangulation on Gene Expression Patterns in Behavioral Responses to Acute Ethanol, by Robnet T. Kerns; (2) Gene Expression in Limbic Regions After Ethanol Self-Infusion Into the Posterior Ventral Tegmental Area, by Zachary A. Rodd; (3) Microarray Analysis of CNS Limbic Regions of Inbred Alcohol-Preferring and -Nonpreferring rats and Effects of Alcohol Drinking, by Wendy N. Strother and Howard J. Edenberg; and (4) Microarray Analysis of Mouse Lines Selected for Chronic Ethanol Withdrawal Severity: The Convergence of Basal, Ethanol Regulated, and Proximity to Ethanol Quantitative Trait Loci to Identify Candidate Genes, by Joel G. Hashimoto and Kristine M. Wiren.

摘要

本文总结了在加拿大不列颠哥伦比亚省温哥华市举行的2004年酒精研究学会年会上举办的一次研讨会的会议记录。组织者和主席是威廉·J·麦克布赖德和迈克尔·F·迈尔斯。发言内容包括:(1)罗伯特·T·克恩斯所做的《急性乙醇行为反应中基因表达模式的分子三角测量》;(2)扎卡里·A·罗德所做的《向后腹侧被盖区自我注射乙醇后边缘区域的基因表达》;(3)温迪·N·斯特罗瑟和霍华德·J·伊登伯格所做的《近交系嗜酒和不嗜酒大鼠中枢神经系统边缘区域的微阵列分析及饮酒的影响》;以及(4)乔尔·G·桥本和克里斯汀·M·怀伦所做的《针对慢性乙醇戒断严重程度选择的小鼠品系的微阵列分析:基础、乙醇调节以及与乙醇数量性状位点的接近程度的融合以鉴定候选基因》。

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