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用于理解酒精作用的DNA微阵列和蛋白质组学策略。

DNA microarray and proteomic strategies for understanding alcohol action.

作者信息

Sikela James M, Maclaren Erik J, Kim Young, Karimpour-Fard Anis, Cai Wei-Wen, Pollack Jonathan, Hitzemann Robert, Belknap John, McWeeney Shannon, Kerns Robnet T, Downing Chris, Johnson Thomas E, Grant Kathleen J, Tabakoff Boris, Hoffman Paula, Wu Christine C, Miles Michael F

机构信息

University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, USA.

出版信息

Alcohol Clin Exp Res. 2006 Apr;30(4):700-8. doi: 10.1111/j.1530-0277.2006.00081.x.

DOI:10.1111/j.1530-0277.2006.00081.x
PMID:16573589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2709534/
Abstract

This article summarizes the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism in Santa Barbara, California. The organizer was James M. Sikela, and he and Michael F. Miles were chairs. The presentations were (1) Genomewide Surveys of Gene Copy Number Variation in Human and Mouse: Implications for the Genetics of Alcohol Action, by James M. Sikela; (2) Regional Differences in the Regulation of Brain Gene Expression: Relevance to the Detection of Genes Associated with Alcohol-Related Traits, by Robert Hitzemann; (3) Identification of Ethanol Quantitative Trait Loci Candidate Genes by Expression Profiling in Inbred Long Sleep/Inbred Short Sleep Congenic Mice, by Robnet T. Kerns; and (4) Quantitative Proteomic Analysis of AC7-Modified Mice, by Kathleen J. Grant.

摘要

本文总结了在加利福尼亚州圣巴巴拉市举行的2005年酒精研究学会年会上举办的一场研讨会的会议记录。组织者是詹姆斯·M·西凯拉,他和迈克尔·F·迈尔斯担任主席。发言内容包括:(1)詹姆斯·M·西凯拉所做的《人类和小鼠基因拷贝数变异的全基因组调查:对酒精作用遗传学的启示》;(2)罗伯特·希茨曼所做的《大脑基因表达调控的区域差异:与酒精相关性状相关基因检测的相关性》;(3)罗布内特·T·克恩斯所做的《通过近交长睡眠/近交短睡眠同类系小鼠的表达谱鉴定乙醇数量性状位点候选基因》;以及(4)凯瑟琳·J·格兰特所做的《AC7基因修饰小鼠的定量蛋白质组学分析》。

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