Levi Fabio, Te Van-Cong, Randimbison Lalao, La Vecchia Carlo
Unité d'Epidémiologie du Cancer and Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, Centre Hospitalier Universitaire Vaudois, Falaises 1, 1011 Lausanne, Switzerland.
Melanoma Res. 2005 Feb;15(1):73-5. doi: 10.1097/00008390-200502000-00012.
The trends in the incidence of various morphological types of cutaneous malignant melanoma (CMM) in the Swiss Cancer Registries of Vaud and Neuchatel (total population 786,000 in 2000) were analysed over the period 1978-2002. Overall, the age-standardized (world) incidence of CMM increased from 5.7/100,000 to 16.8/100,000 for men (+195%) and from 7.9/100,000 to 18.7/100,000 for women (+137%). However, there was no consistent trend for nodular melanoma and other or unspecified morphological types, and the upward trends were observed for lentigo maligna melanoma (from 0.2/100,000 to 1.5/100,000 for men and from 0.5/100,000 to 2.1/100 000 for women) and mainly superficial spreading melanoma [from 2.5/100,000 to 10.2/100,000 for men (+308%) and from 3.3/100,000 to 12.3/100,000 for women (+273%)]. This has implications for aetiology, as the various morphological types of CMM may have different determinants, and for prevention, as the rise in superficial spreading melanomas, which are comparatively thin, may explain the increased survival rates registered for CMM over the last three decades.
对沃州和纳沙泰尔州瑞士癌症登记处（2000年总人口78.6万）1978 - 2002年期间各种形态类型的皮肤恶性黑色素瘤（CMM）发病率趋势进行了分析。总体而言，CMM的年龄标准化（世界）发病率男性从5.7/10万增至16.8/10万（增长195%），女性从7.9/10万增至18.7/10万（增长137%）。然而，结节性黑色素瘤以及其他或未明确形态类型并无一致趋势，而恶性雀斑样痣黑色素瘤呈上升趋势（男性从0.2/10万增至1.5/10万，女性从0.5/10万增至2.1/10万），主要是浅表扩散性黑色素瘤[男性从2.5/10万增至10.2/10万（增长308%），女性从3.3/10万增至12.3/10万（增长273%）]。这对病因学有影响，因为CMM的各种形态类型可能有不同的决定因素，对预防也有影响，因为相对较薄的浅表扩散性黑色素瘤的增加可能解释了过去三十年CMM登记生存率的提高。
