Klotz S A
Department of Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128-2295.
Clin Infect Dis. 1992 Jan;14(1):340-7. doi: 10.1093/clinids/14.1.340.
The importance of adherence of Candida albicans to the vascular structures in the pathogenesis of disseminated candidiasis is discussed. The evidence for adherence of this fungus to endothelial cells and to the subendothelial basement membrane in vivo is reviewed, as are the data documenting these events in vitro. Information on the subcellular interactions of the host's vascular structures with this pathogen is presented. For example, the C. albicans surface receptors for iC3b, laminin, and fibronectin are discussed in light of their possible ability to mediate the adherence of the fungus to vascular structures. The review is concluded with a potentially unifying concept of integrin-like receptors on Candida that bind arginine-glycine-aspartic acid-containing peptides that may account for the binding of numerous human proteins to C. albicans.
本文讨论了白色念珠菌黏附于血管结构在播散性念珠菌病发病机制中的重要性。综述了该真菌在体内黏附于内皮细胞和内皮下基底膜的证据，以及在体外记录这些事件的数据。还介绍了宿主血管结构与该病原体的亚细胞相互作用信息。例如，根据其介导真菌黏附于血管结构的可能能力，讨论了白色念珠菌表面的iC3b、层粘连蛋白和纤连蛋白受体。综述最后提出了一个关于念珠菌上整合素样受体的潜在统一概念，该受体结合含精氨酸-甘氨酸-天冬氨酸的肽，这可能解释了多种人类蛋白与白色念珠菌的结合。
