表皮干细胞：表皮决定、分化及伤口愈合的摇篮
Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing.
作者信息
Morasso Maria I, Tomic-Canic Marjana
机构信息
Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Biol Cell. 2005 Mar;97(3):173-83. doi: 10.1042/BC20040098.
Abstract
The field of epidermal stem cells has dramatically advanced in the last decade, leading to a better understanding of the molecular factors, signalling pathways and cellular events that identify and characterize stem cells, thus revealing their immense potential for therapeutic use. Furthermore, multipotent epidermal stem cells present the major advantage of easy accessibility with the discovery of their specific location within the bulge of the hair follicle. This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin.
摘要
在过去十年中，表皮干细胞领域取得了显著进展，使人们对识别和表征干细胞的分子因素、信号通路及细胞事件有了更深入的了解，从而揭示了它们在治疗应用中的巨大潜力。此外，随着多能表皮干细胞在毛囊隆突部特定位置的发现，其具有易于获取的主要优势。本综述聚焦于表皮干细胞的最新研究成果，以及它们在皮肤表皮初始定向、分化和伤口愈合过程中的潜在作用。
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