Garcin Clare L, Ansell David M
The Healing Foundation Centre, The Faculty of Life Sciences, University of Manchester, Manchester, UK.
The Centre for Dermatology Research, The Institute of Inflammation & Repair, The University of Manchester, Manchester, UK.
Exp Dermatol. 2017 Feb;26(2):101-104. doi: 10.1111/exd.13184.
The hair follicle has an established role in wound re-epithelialisation, a phenomenon that has been appreciated since at least the first half of the last century. The bulge niche, one location of hair follicle epithelial stem cells has been of particular interest to researchers over recent years, with numerous studies showing its ability to directly contribute to epidermal repair. However, recent work has highlighted other progenitor regions of the hair follicle that appear to act as stem cells during epidermal repair. In addition, several studies within the last 12 months have questioned the importance of the bulge during re-epithelialisation, producing conflicting literature. Here we provide a new model to demonstrate how several important differences in experimental design between studies could account for these seemingly opposing findings, which may have implications for how future studies are conducted.
毛囊在伤口再上皮化过程中发挥着既定作用，这一现象至少从上世纪上半叶起就已为人所知。毛囊上皮干细胞所在的隆突区龛近年来尤其受到研究人员的关注，大量研究表明其能够直接促进表皮修复。然而，最近的研究工作突出了毛囊中其他祖细胞区域，这些区域在表皮修复过程中似乎起着干细胞的作用。此外，过去12个月内的几项研究对隆突区在再上皮化过程中的重要性提出了质疑，产生了相互矛盾的文献。在此，我们提供了一个新模型，以说明研究之间实验设计的几个重要差异如何能够解释这些看似相反的发现，这可能对未来研究的开展方式产生影响。
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