Fukshansky N, Bär W
Birkenstrasse 4B, 79256 Buchenbach, Germany.
Int J Legal Med. 2005 Sep;119(5):285-90. doi: 10.1007/s00414-004-0497-5. Epub 2005 Feb 17.
The conventional theory for interpreting forensic DNA evidence developed for the autosomal genetic markers is not applicable in the case of haplotypic markers, specifically for Y-STR based data. The reason is, that in contrast to the case of autosomal markers, single alleles found in the mixed stain cannot be assigned to unknown stain contributors independently of each other, while the assignable entities are sets of linked alleles which should be treated as non-separable units. It is shown that the conventional theory cannot be extended to this situation. A novel theory which accounts for the features of haplotypic markers has been developed within the general framework of the hypotheses testing approach. This theory opens the way for the use of haplotypic markers in the analysis of mixed stains with the arbitrary numbers of unknown contributors and linked loci. A numerical example demonstrates the application of the theory.
为常染色体遗传标记开发的用于解释法医DNA证据的传统理论不适用于单倍型标记的情况，特别是基于Y-STR的数据。原因是，与常染色体标记的情况不同，在混合样本中发现的单个等位基因不能相互独立地分配给未知样本贡献者，而可分配的实体是连锁等位基因的集合，应将其视为不可分割的单位。结果表明，传统理论不能扩展到这种情况。在假设检验方法的一般框架内，已经开发出一种考虑单倍型标记特征的新理论。该理论为在具有任意数量未知贡献者和连锁位点的混合样本分析中使用单倍型标记开辟了道路。一个数值例子展示了该理论的应用。
