Hara Hitoshi, Oyama Toshio, Suda Koichi
Department of Biochemistry, Akebono Medical Welfare Center, and Pathology Division, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.
Acta Cytol. 2005 Jan-Feb;49(1):43-50. doi: 10.1159/000326094.
To formulate new criteria for adenoid cystic carcinoma (ADCC).
The usefulness of 17 items for a cytologically definitive diagnosis of ADCC was examined. The frequency (- - +++) of the 17 items in 18 cases of ADCC and 10 non-ADCC cases (pleomorphic adenoma, basal cell adenoma, myoepithelioma and epithelial-myoepithelial carcinoma) that displayed mimicking cytology was examined cytologically. The total score for cases of ADCC was compared with that for non-ADCC cases.
The 17 items included broad intercellular spaces with adhesion; green, granular/cobwebby cytoplasm with translucent intercellular matrix with Papanicolaou staining; coarse hyperchromatin with little nuclear clearing; indistinct and partially distinct nucleoli; small nuclei; broad, smooth margin (SM) space; and translucent M/HG/SM. All cases with a total score of > 21 were ADCC (93.8%). All cases with a total score of < 12 were non-ADCC (87.5%).
The 17 items appear to be useful as new criteria for ADCC.
制定腺样囊性癌（ADCC）的新诊断标准。
对17项用于ADCC细胞学确诊的指标进行实用性检验。对18例ADCC病例以及10例具有相似细胞学表现的非ADCC病例（多形性腺瘤、基底细胞腺瘤、肌上皮瘤和上皮-肌上皮癌）的17项指标出现频率（- - +++）进行细胞学检查。比较ADCC病例与非ADCC病例的总分。
17项指标包括细胞间间隙宽且有黏附；巴氏染色下细胞质呈绿色、颗粒状/蛛网状，细胞间基质半透明；染色质粗糙、深染，核仁很少；核仁不清晰且部分清晰；细胞核小；边缘宽且光滑（SM）间隙；半透明的M/HG/SM。总分> 21分的所有病例均为ADCC（93.8%）。总分< 12分的所有病例均为非ADCC（87.5%）。
这17项指标似乎可作为ADCC的新诊断标准。
