Park H S, Lee K
Department of Family Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Diabet Med. 2005 Mar;22(3):266-72. doi: 10.1111/j.1464-5491.2004.01395.x.
To evaluate the effect of weight reduction on parameters of the metabolic syndrome in obese patients according to their pattern of abdominal fat distribution.
A longitudinal intervention study, consisting of a 12-week weight reduction programme, including lifestyle modification and adjuvant appetite suppressant, in 38 subjects with visceral obesity and 47 subjects with subcutaneous obesity. Visceral, subcutaneous and total adipose tissue areas were determined by CT scan at the level of L4-L5. Parameters for components of the metabolic syndrome were measured before and after weight reduction.
Reductions in body weight, BMI and subcutaneous adipose tissue area were greater in the subcutaneous than in the visceral obesity group. In contrast, changes in fasting plasma glucose, insulin, and HOMA score were higher in the visceral than in the subcutaneous obesity group. Changes in visceral adipose tissue area were significantly related to changes in fasting plasma glucose, triglycerides and HOMA score.
Visceral fat reduction induced greater beneficial effects on parameters of the metabolic syndrome than subcutaneous fat reduction. Evaluation of changes in abdominal fat distribution is necessary when obese subjects enter a weight reduction programme.
根据肥胖患者腹部脂肪分布模式，评估体重减轻对代谢综合征各项参数的影响。
一项纵向干预研究，对38例内脏型肥胖患者和47例皮下型肥胖患者进行为期12周的体重减轻计划，包括生活方式改变和辅助性食欲抑制剂。通过L4-L5水平的CT扫描确定内脏、皮下和总脂肪组织面积。在体重减轻前后测量代谢综合征各组分的参数。
皮下型肥胖组的体重、BMI和皮下脂肪组织面积的下降幅度大于内脏型肥胖组。相比之下，内脏型肥胖组空腹血糖、胰岛素和HOMA评分的变化高于皮下型肥胖组。内脏脂肪组织面积的变化与空腹血糖、甘油三酯和HOMA评分的变化显著相关。
减少内脏脂肪比减少皮下脂肪对代谢综合征参数产生更大的有益影响。肥胖患者进入体重减轻计划时，评估腹部脂肪分布的变化是必要的。
