Park Hye Soon, Sim Su Jung, Park Jung Yul
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Korean Med Sci. 2004 Apr;19(2):202-8. doi: 10.3346/jkms.2004.19.2.202.
The Third Report of the National Cholesterol Education Program Adult Treatment Panel III emphasized the importance of management of the metabolic syndrome. However, little information is available about the effect of weight reduction on the metabolic syndrome in obese patients among Koreans. A longitudinal clinical intervention study from the 12-week of weight reduction program, including life style modification and adjuvant appetite suppressants, in 78 obese persons was performed. Anthropometry and metabolic risk factors were measured before and after weight reduction. Visceral (VAT), subcutaneous (SAT), and total adipose tissue (TAT) on abdomen were determined by CT scan. Moderate decrease in weight (9.3%) induced significant reduction of waist circumference, systolic and diastolic blood pressure, and triglyceride. Weight reduction also resulted in significant decrease in total cholesterol, LDL-C, uric acid, fasting insulin, and HOMA score. The subjects with metabolic syndrome showed more improvements of metabolic components than those without metabolic syndrome through weight reduction. The reductions of visceral-subcutaneous fat ratio (VSR) and waist circumference were observed as for the predictable variables related to the improvement of metabolic component and insulin resistance in Korean obese patients.
美国国家胆固醇教育计划成人治疗小组第三次报告强调了代谢综合征管理的重要性。然而，关于减肥对韩国肥胖患者代谢综合征的影响，目前可用信息很少。我们对78名肥胖者进行了一项为期12周的减肥计划的纵向临床干预研究，该计划包括生活方式改变和辅助性食欲抑制剂。在减肥前后测量人体测量学指标和代谢危险因素。通过CT扫描测定腹部的内脏脂肪（VAT）、皮下脂肪（SAT）和总脂肪组织（TAT）。体重适度下降（9.3%）导致腰围、收缩压和舒张压以及甘油三酯显著降低。减肥还导致总胆固醇、低密度脂蛋白胆固醇、尿酸、空腹胰岛素和HOMA评分显著下降。与无代谢综合征的受试者相比，患有代谢综合征的受试者通过减肥在代谢成分方面有更多改善。在韩国肥胖患者中，观察到内脏与皮下脂肪比率（VSR）和腰围的降低与代谢成分改善和胰岛素抵抗相关的可预测变量有关。
