Likimani S, Whitford G M, Kunkel M E
Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta 30912-1129.
Calcif Tissue Int. 1992 Feb;50(2):157-64. doi: 10.1007/BF00298794.
This study examined the effects of chronic protein deficiency and fluoride administration (10 mg/kg/day), separately or in combination, on rat tibia properties. Protein deficiency increased the bone fluoride concentration and reduced the bone mineral content (BMC) especially at the proximal or growing end which contains mainly cancellous bone. Fluoride administration also reduced BMC, but to a lesser extent, and it resulted in proximal tibia fluoride concentrations that were nearly twice those of the distal tibia. The interaction between fluoride administration and the protein content of the diet on BMC was nonsignificant, suggesting that the effects were additive, not multiplicative or synergistic. Fluoride administration, but not protein deficiency, increased bone magnesium levels. It is hypothesized that the reduction in BMC in the areas where the fluoride concentrations were the highest was due to a localized toxic effect of fluoride.
本研究分别或联合检测了慢性蛋白质缺乏和给予氟化物（10毫克/千克/天）对大鼠胫骨特性的影响。蛋白质缺乏增加了骨氟浓度，并降低了骨矿物质含量（BMC），尤其是在主要包含松质骨的近端或生长端。给予氟化物也降低了BMC，但程度较小，并且导致近端胫骨氟浓度几乎是远端胫骨的两倍。给予氟化物与饮食中蛋白质含量对BMC的相互作用不显著，表明这些影响是相加的，而非相乘或协同的。给予氟化物增加了骨镁水平，但蛋白质缺乏未产生此效果。据推测，氟浓度最高区域的BMC降低是由于氟的局部毒性作用。
