Cena H, Toselli A, Biino G
Section of Human Nutrition, Department of Health Applied Sciences, University of Pavia, Pavia, Italy.
Minerva Gastroenterol Dietol. 2004 Mar;50(1):79-87.
The aim of the present study was to evaluate serum lipid abnormalities and the relationship with various factors in overweight and obese patients and to assess lipid profile modifications subsequent to weight loss in a subgroup of patients.
A sample of 110 obese out-patients first and a subgroup of 34 subjects afterwards, was selected at the Human Nutrition Research Centre of the University of Pavia for a retrospective analysis. The subjects recruited were all dyslipidemic, according to the American Clinical Guidelines for the assessment of cardiovascular risk. Differences in lipid profiles in subjects with different life habits were evaluated and in a subgroup of 34 subjects compared before and after a short-term moderate hypocaloric diet.
Sample's mean age was 46.8+/-12.6 with a mean body mass index (BMI) of 32.1+/-4.8 kg/m2 (no difference with gender). The correlation analyses showed that total cholesterol (TC) concentrations were highly correlated with age (p<0.001); no correlation was found between TC and BMI, waist hip ratio (WHR), % body fat (BF%). Triglycerides (TG) concentrations were not related to age or BMI, however there was a significant correlation between TG and WHR and with waist circumference (WC) (p<0.001). The 34 subjects selected to take part in a dietary regimen, without significant changes in life habits, lost 5.1% of their initial weight and presented a significant improvement (p<0.001) in lipid profile.
The high correlation between lipid profile and anthropometric measurements implies further longitudinal evaluation of the validity of the anthropometric indexes in the dyslipidemic patient management. Indeed, the results suggest that modest weight loss is sufficient to obtain a significant improvement in fasting serum lipid profile of dyslipidemic overweight patients.
本研究旨在评估超重和肥胖患者的血脂异常情况及其与各种因素的关系，并评估部分患者体重减轻后的血脂谱变化。
在帕维亚大学人类营养研究中心选取了110名肥胖门诊患者作为样本，随后又选取了34名受试者作为子样本进行回顾性分析。根据美国心血管风险评估临床指南，招募的受试者均患有血脂异常。评估了不同生活习惯受试者的血脂谱差异，并对34名受试者在短期适度低热量饮食前后的血脂谱进行了比较。
样本的平均年龄为46.8±12.6岁，平均体重指数（BMI）为32.1±4.8kg/m²（性别间无差异）。相关性分析表明，总胆固醇（TC）浓度与年龄高度相关（p<0.001）；未发现TC与BMI、腰臀比（WHR）、体脂百分比（BF%）之间存在相关性。甘油三酯（TG）浓度与年龄或BMI无关，但TG与WHR和腰围（WC）之间存在显著相关性（p<0.001）。被选参与饮食方案的34名受试者，在生活习惯无显著变化的情况下，体重减轻了初始体重的5.1%，血脂谱有显著改善（p<0.001）。
血脂谱与人体测量指标之间的高度相关性意味着需要对人体测量指标在血脂异常患者管理中的有效性进行进一步的纵向评估。事实上，结果表明适度的体重减轻足以使血脂异常的超重患者的空腹血脂谱得到显著改善。
