Klement W, Arndt J O
Abteilung für Experimentelle Anaesthesiologie der Heinrich-Heine-Universität, Düsseldorf, Germany.
Cardiovasc Res. 1992 Feb;26(2):186-9. doi: 10.1093/cvr/26.2.186.
The pain evoking and pain modulating properties of adenosine were studied at venous and paravascular nociceptors in humans.
In six volunteers, adenosine (3 to 15.10(-3) M) was perfused continuously through vascularly isolated segments of dorsal hand veins or injected into occluded finger veins. The effects of adenosine on pain evoked by intravenous electrostimulation of hand veins were also studied. The subjects rated the pain intensities on a visual analogue scale.
Adenosine neither evoked pain nor altered the intensities of electrically evoked pain.
Adenosine does not mediate or modulate pain via venous or paravascular nociceptors. Therefore these nociceptors are unlikely to be involved in adenosine related ischaemia pain.
研究腺苷在人体静脉和血管旁伤害感受器上的致痛和痛觉调制特性。
在6名志愿者中，将腺苷（3至15×10⁻³ M）持续灌注到背侧手静脉的血管隔离段中，或注入被阻断的手指静脉中。还研究了腺苷对静脉电刺激手部静脉诱发疼痛的影响。受试者通过视觉模拟量表对疼痛强度进行评分。
腺苷既不诱发疼痛，也不改变电诱发疼痛的强度。
腺苷不通过静脉或血管旁伤害感受器介导或调制疼痛。因此，这些伤害感受器不太可能参与与腺苷相关的缺血性疼痛。
