Kindgen-Milles D, Klement W, Arndt J O
Department of Experimental Anaesthesiology, Heinrich Heine University Düsseldorf, Germany.
Neurosci Lett. 1994 Nov 7;181(1-2):39-42. doi: 10.1016/0304-3940(94)90555-x.
To study the pain-evoking properties of bradykinn on the nociceptive systems of skin, paravascular tissue and hand veins of humans, bradykinin was injected intracutaneously, retrogradially into occluded finger veins for reaching the paravascular tissue or into vascularly isolated hand vein segments of seven subjects. Regardless of the injection site, bradykinin always evoked pain of concentration-related intensity within nearly similar concentration ranges of 0.1-10.0 microM, yielding congruent pain intensity-concentration relations. Thus, in humans, the nociceptive systems of skin, deep tissue and hand veins are equally sensitive to the endogenous algetic bradykinin.
为研究缓激肽对人体皮肤、血管周围组织和手部静脉伤害性感受系统的致痛特性，将缓激肽皮内注射、逆行注入闭塞的手指静脉以到达血管周围组织或注入7名受试者经血管分离的手部静脉段。无论注射部位如何，缓激肽在0.1 - 10.0微摩尔的相近浓度范围内总能引起与浓度相关强度的疼痛，产生一致的疼痛强度 - 浓度关系。因此，在人体中，皮肤、深部组织和手部静脉的伤害性感受系统对内源性致痛缓激肽同样敏感。
