Richardson Des R
Iron Metabolism and Chelation Program, Children's Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW 2031, Australia.
Biochem J. 2005 Mar 1;386(Pt 2):e5-7. doi: 10.1042/BJ20050149.
How is the essential micronutrient, selenium (Se), transported in the serum and then donated to tissues? In this issue of the Biochemical Journal, Schweizer and colleagues demonstrate, using conditional and total mouse knockout models, that SePP (selenoprotein P) is the major transporter of Se in the serum. Moreover, in the sanctuary area of the brain, SePP was shown to play a hitherto unexpected role as a local Se storage and recycling protein that directly maintains brain Se levels. Considering the function of Se in normal brain metabolism, these results are crucial for our understanding of the role of selenoproteins in redox regulation, antioxidant defences, thyroid hormone metabolism and the development of neurodegenerative conditions.
必需微量营养素硒（Se）是如何在血清中运输并随后输送到组织中的？在本期《生物化学杂志》中，施韦泽及其同事利用条件性和完全敲除小鼠模型证明，硒蛋白P（SePP）是血清中硒的主要转运蛋白。此外，在大脑的保护区，SePP被证明作为一种局部硒储存和循环利用蛋白发挥了迄今为止意想不到的作用，直接维持大脑中的硒水平。考虑到硒在正常脑代谢中的功能，这些结果对于我们理解硒蛋白在氧化还原调节、抗氧化防御、甲状腺激素代谢以及神经退行性疾病发展中的作用至关重要。
