ATP-stimulated glutamate-dependent calcium uptake by rat synaptosomes.
作者信息
Galzigna L, Bianchi M, Battistin T, Scarpa M, Rigo A
机构信息
Department of Biological Chemistry, University of Padova, Italy.
出版信息
Clin Chim Acta. 1992 Mar 13;206(1-2):147-53. doi: 10.1016/0009-8981(92)90015-i.
PMID:1572076
Abstract
The entry of Ca2+ in rat synaptosomes was followed with a Ca(2+)-selective electrode. Extracellular ATP is necessary for the entry which is a function of synaptosomal protein, free Ca2+ and glutamate concentrations. Ketamine, glycine and kainate have negligible effect while quisqualate slightly inhibits the uptake of Ca2+ in the presence of glutamate. The added ATP is hydrolyzed by the synaptosomes through an ouabain-insensitive ecto-ATPase affected by the presence of Ca2+, glutamate and, to a slight extent, NMDA.
摘要
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