Bianco Roberto, de Rosa Gaetano, Staibano Stefania, Somma Pasquale, Bianco Angelo Raffaele
Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università Federico II, Nuovo Policlinico, Via S. Pansini 5, 80131 Naples, Italy.
Gynecol Oncol. 2005 Mar;96(3):846-9. doi: 10.1016/j.ygyno.2004.10.044.
Luteinized thecoma of the ovary associated with sclerosing peritonitis is a rare pathologic condition without a standard strategy of treatment.
We present the case of an ovarian luteinizing sclerosing thecoma in a 39-year-old woman. The patient underwent three laparotomic operations for subocclusive symptoms, revealing in both occasions the presence of sclerosing peritonitis, with large abdominal masses, including cysts containing clear fluid. Treatment with toremifene 20 mg/day and leuprolide resulted in a dramatic improvement of the performance status and complete remission of all the abdominal lesions. After 60 months follow-up, the patient is still disease-free.
Antiestrogens plus LHRH agonists might be a noninvasive, effective and well-tolerated therapy for sclerosing peritonitis in patient operated for luteinized thecomas.
卵巢黄素化卵泡膜细胞瘤合并硬化性腹膜炎是一种罕见的病理状况，尚无标准的治疗策略。
我们报告一例39岁女性的卵巢黄素化硬化性卵泡膜细胞瘤。该患者因亚闭塞症状接受了三次剖腹手术，两次均发现存在硬化性腹膜炎，伴有巨大腹部肿块，包括含有清亮液体的囊肿。每日服用20毫克托瑞米芬和亮丙瑞林治疗后，患者的身体状况显著改善，所有腹部病变完全缓解。随访60个月后，患者仍无疾病复发。
对于因黄素化卵泡膜细胞瘤接受手术的患者，抗雌激素药物联合促性腺激素释放激素激动剂可能是一种无创、有效且耐受性良好的硬化性腹膜炎治疗方法。
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