Johnson David A
Department of Gastroenterology, Eastern Virginia School of Medicine, 700 W. Olney Road, Norfolk, VA 23501, USA.
Gastrointest Endosc Clin N Am. 2005 Apr;15(2):333-45. doi: 10.1016/j.giec.2004.10.012.
Gastroesophageal reflux disease (GERD) typically requires lifelong medical therapy or surgery for the management of patients with frequent symptoms. The current standard of care is to prescribe medical therapy using proton pump inhibitors. Patients with moderate-to-severe GERD require extended/maintenance therapy. Until recently, the only alternative to this approach was surgical intervention. Endoscopic therapy for GERD has emerged as a second alternative strategy. Primary endpoints for all interventions have aimed at symptomatic control and reduction/discontinuance of medication use. For surgical and endoscopic therapies, however, there are other physiologic endpoints that have attempted to define changes in lower esophageal sphincter pressure and esophageal acid exposure. For patients being evaluated for endoscopic GERD therapy, the author recommends comprehensive esophageal testing and pH testing.
胃食管反流病（GERD）通常需要终身药物治疗或手术来管理频繁出现症状的患者。目前的护理标准是使用质子泵抑制剂进行药物治疗。中重度GERD患者需要长期/维持治疗。直到最近，这种方法的唯一替代方案是手术干预。GERD的内镜治疗已成为第二种替代策略。所有干预措施的主要终点都旨在控制症状以及减少/停用药物。然而，对于手术和内镜治疗，还有其他生理终点试图定义食管下括约肌压力和食管酸暴露的变化。对于接受内镜GERD治疗评估的患者，作者建议进行全面的食管检测和pH检测。
