Gallagher Romayne E, Arndt Douglas R, Hunt Krista L
Division of Palliative Care and Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada.
Clin J Pain. 2005 Mar-Apr;21(2):190-2. doi: 10.1097/00002508-200503000-00012.
Topical morphine has been used on open wounds for pain management, but has a variable duration of action not suitable for palliative dressing changes. The objective of this study is to find an opioid and delivery method that would provide long-lasting pain relief between dressing changes. Methadone powder (100 mg) was mixed in Stomahesive powder (10 g) and sprinkled on the open wound once daily at the time of dressing change. Four cases are presented with varying results using the methadone/Stomahesive mixture. Exudative wounds with exposed tissue work best, whereas dry wounds with eschar show less response. Topical methadone powder can be effective for pain relief in open, exudative wounds with little eschar. Further research questions are raised.
局部用吗啡已用于开放性伤口的疼痛管理，但作用持续时间不一，不适合用于姑息性换药。本研究的目的是找到一种阿片类药物及其给药方法，以便在换药期间提供持久的疼痛缓解。将美沙酮粉末（100毫克）混入造口黏附粉（10克）中，在换药时每天一次撒在开放性伤口上。本文介绍了4例使用美沙酮/造口黏附粉混合物的不同结果。有暴露组织的渗出性伤口效果最佳，而有焦痂的干性伤口反应较小。局部用美沙酮粉末对开放性、渗出性且几乎没有焦痂的伤口的疼痛缓解可能有效。由此提出了进一步的研究问题。
