羟考酮在烧伤创面手术治疗后换药中的镇痛效果：一项随机对照试验
Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial.
作者信息
Kowalski Grzegorz, Leppert Wojciech, Domagalska Małgorzata, Grochowicka Monika, Teżyk Artur, Słowiński Krzysztof, Bienert Agnieszka, Szkutnik-Fiedler Danuta, Wieczorowska-Tobis Katarzyna
机构信息
Department of Palliative Medicine, Poznan University of Medical Sciences, 61-701 Pozan, Poland.
Department of Anesthesiology, Józef Struś Multiprofile Municipal Hospital, 61-701 Poznań, Poland.
出版信息
J Clin Med. 2024 Jan 29;13(3):784. doi: 10.3390/jcm13030784.
INTRODUCTION
This study aimed to assess the analgesic efficacy of oxycodone at doses of 10 mg and 20 mg in dressings after surgery of burn wounds.
MATERIAL AND METHODS
Twenty adult patients who underwent surgical treatment of third-degree burn wounds under general anaesthesia were included. Burn wounds were treated with dressings, to which oxycodone was added at 20 mg in Group 1 and 10 mg in Group 2. After the surgery, plasma oxycodone and noroxycodone concentrations were assayed, and pain intensity was assessed with Numerical Rating Scale (NRS).
RESULTS
In Group 1, no patient reported pain; in Group 2, four patients reported pain. The pain intensity, according to NRS, was 1-8. Plasma concentration of oxycodone in the blood serum was in the range of 1.24-3.15 ng/mL and 1.09-1.28 ng/mL in Group 1 and Group 2, respectively. Noroxycodone was not detected in the plasma. Adverse effects were not observed in any of the treated patients.
CONCLUSIONS
Oxycodone in dressings provides patients with adequate and safe analgesia.
引言
本研究旨在评估10毫克和20毫克剂量的羟考酮在烧伤创面手术后敷料中的镇痛效果。
材料与方法
纳入20例在全身麻醉下接受三度烧伤创面手术治疗的成年患者。烧伤创面用敷料治疗，第1组在敷料中添加20毫克羟考酮，第2组添加10毫克。手术后，测定血浆中羟考酮和去甲羟考酮的浓度，并用数字评分量表（NRS）评估疼痛强度。
结果
第1组无患者报告疼痛；第2组有4例患者报告疼痛。根据NRS，疼痛强度为1-8。第1组和第2组血清中羟考酮的血浆浓度分别为1.24-3.15纳克/毫升和1.09-1.28纳克/毫升。血浆中未检测到去甲羟考酮。在任何接受治疗的患者中均未观察到不良反应。
结论
敷料中的羟考酮为患者提供了充分且安全的镇痛效果。
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