Purper-Ouakil D, Wohl M, Mouren M C, Verpillat P, Adès J, Gorwood P
CHU Robert Debré (AP-HP, Paris VII), Paris, France.
Psychiatr Genet. 2005 Mar;15(1):53-9. doi: 10.1097/00041444-200503000-00009.
Molecular genetic research has mainly focused on the D4 dopamine receptor (DRD4) and the dopamine transporter (DAT) genes in attention-deficit hyperactivity disorder (ADHD). A recent meta-analysis showed that the DRD4 gene has a significant role in the vulnerability to ADHD.
With an equal number of positive and negative association studies between the 10-repeat of the DAT gene and ADHD, a meta-analysis is required for this other candidate gene.
We re-analysed the 13 published family-based association studies between ADHD and the DAT gene. Following recent recommendations, different biases were specifically assessed, such as the sample-size effect and the time effect.
The meta-analysis showed no significant association between ADHD and the DAT gene (P = 0.21), but an important between-samples heterogeneity (P = 0.0009). Odds ratios above 1 are mostly observed in studies with a small number of informative transmissions, and decrease with larger sample size.
Contrary to what was found for the DRD4 gene, the 10-repeat allele of the DAT gene has at most a minor role in the genetic susceptibility of ADHD. The different biases detected herein probably explain the initial impression of a significant impact of the DAT gene on hyperactivity.
分子遗传学研究主要聚焦于注意力缺陷多动障碍（ADHD）中的D4多巴胺受体（DRD4）基因和多巴胺转运体（DAT）基因。最近的一项荟萃分析表明，DRD4基因在ADHD易感性中起重要作用。
由于DAT基因10重复序列与ADHD之间的阳性和阴性关联研究数量相等，因此需要对这个其他候选基因进行荟萃分析。
我们重新分析了13项已发表的基于家系的ADHD与DAT基因关联研究。根据最近的建议，特别评估了不同的偏倚，如样本量效应和时间效应。
荟萃分析显示ADHD与DAT基因之间无显著关联（P = 0.21），但样本间存在重要的异质性（P = 0.0009）。比值比大于1主要出现在信息传递数量较少的研究中，并随着样本量的增加而降低。
与DRD4基因的情况相反，DAT基因的10重复等位基因在ADHD的遗传易感性中至多起次要作用。本文检测到的不同偏倚可能解释了最初认为DAT基因对多动有显著影响的印象。
