Raleigh Daniel P, Plaxco Kevin W
Department of Chemistry, Graduate Program in Biochemistry and Structural Biology, State University of New York at Stony Brook, NY 11794-3400, USA.
Protein Pept Lett. 2005 Feb;12(2):117-22. doi: 10.2174/0929866053005809.
Protein engineering-based studies of the folding transition state have accelerated significantly in the last decade, and more than a half dozen proteins have been subjected to extensive Phi-value analysis. A general picture is emerging from these studies of a transition state in which the large majority of experimentally characterized side chains participate in relatively homogeneous and energetically weak interactions playing only a relatively small role in defining relative folding rates.
