Senda M, Fishman A J, Weise S, Alpert N M, Correia J A, Rubin R H, Strauss H W
Department of Radiology, Massachusetts General Hospital, Boston 02114.
Eur J Nucl Med. 1992;19(3):166-72. doi: 10.1007/BF00173276.
Infection causes remarkable changes in extracellular fluid volume, blood flow and oxygen consumption in the region of the lesion. To determine the sequence and magnitude of these changes, we performed serial scintigraphic measurements in 10 rabbits with experimental Escherichia coli abscesses. Positron emission tomography with C15O2, 15O2 and 11CO was used to measure regional blood flow, oxygen extraction (OEF) and blood volume; extracellular fluid volume was evaluated by single photon scintigraphy with indium-111 immunoglobulin G (IgG). Images were recorded following tracer administration at 1 and 7-10 days after infection. At the first imaging time, blood flow to infected muscle had increased by 40% compared with control sites (7.4 +/- 0.6 to 10.8 +/- 3.8 ml/min.100 g), OEF had decreased from 55% +/- 34% to 45% +/- 14%, and the infected-to-contralateral (I/C) ratio of IgG had increased to 3.34 +/- 1.85. At the later imaging time, flow had increased by almost threefold compared with day 1 (29.4 +/- 9.8 ml/min.100 g), OEF had decreased to 29% +/- 14%, and the I/C ratio for IgG had remained constant. Although OEF fell, oxygen delivery (OEF x flow) increased from 4.07 ml/min (control value) to 4.86 ml/min on day 1 and 8.64 ml/min on days 7-9. The infected-to-contralateral (IC) ratio of 15O2/C15O2 was 0.74 +/- 0.15 on day 1 and 0.77 +/- 0.10 at 7-9 days. These studies indicate that expansion of the extracellular fluid volume increases early in the evolution of the infection and exceeds changes in regional perfusion and oxygen delivery.
感染会导致病变区域的细胞外液量、血流量和氧消耗发生显著变化。为了确定这些变化的顺序和程度，我们对10只患有实验性大肠杆菌脓肿的兔子进行了系列闪烁扫描测量。使用C15O2、15O2和11CO正电子发射断层扫描来测量局部血流量、氧摄取率（OEF）和血容量；通过用铟 - 111免疫球蛋白G（IgG）进行单光子闪烁扫描来评估细胞外液量。在感染后第1天以及7 - 10天给予示踪剂后记录图像。在首次成像时，与对照部位相比，感染肌肉的血流量增加了40%（从7.4±0.6增加到10.8±3.8 ml/min·100g），OEF从55%±3.4%降至45%±1.4%，IgG的感染侧与对侧（I/C）比值增加到3.34±1.85。在随后的成像时，与第1天相比血流量增加了近三倍（29.4±9.8 ml/min·100g），OEF降至29%±1.4%，IgG的I/C比值保持不变。尽管OEF下降，但氧输送量（OEF×血流量）在第1天从4.07 ml/min（对照值）增加到4.86 ml/min，在第7 - 9天增加到8.64 ml/min。15O2/C15O2的感染侧与对侧（IC）比值在第1天为0.74±0.15，在第7 - 9天为0.77±0.10。这些研究表明，在感染演变早期细胞外液量增加，且超过局部灌注和氧输送的变化。
