Varvarigou A D, Archimandritis S C, Stripsanelli A, Arka A, Kostamis P
National Center of Scientific Research Demokritos Aghia Paraskevi, Athens, Greece.
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):267-72. doi: 10.1007/BF03189350.
In the present investigation we have human immunoglobulin labelled with 99Tc(m), applying two different systems. The radiochemical characteristics of the labelled antibody were studied by conventional, radioanalytical methods. Further on, pharmacokinetics of this 99Tc(m)-labelled biomolecule were investigated, by i.v. administration in women, checked for tumours of the ovaries, uterus and cervix. Scintigraphic findings were compared to the results of other imaging techniques (CT, US, X rays), as well as to surgical findings. Our studies indicated that 99Tc(m)-human immunoglobuline can be applied successfully for the scintigraphic detection of several malignant and benign tumours of the female genital system. Tumour accumulation is probably due to the activation of particular cells, as macrophages and lymphocytes, responsible for inflammatory and immunological responses.
在本研究中，我们使用两种不同的系统对标记有99Tc(m)的人免疫球蛋白进行了研究。通过传统的放射分析方法研究了标记抗体的放射化学特性。此外，通过静脉注射给药于患有卵巢、子宫和宫颈癌的女性，研究了这种99Tc(m)标记生物分子的药代动力学。将闪烁扫描结果与其他成像技术（CT、超声、X射线）的结果以及手术结果进行了比较。我们的研究表明，99Tc(m) - 人免疫球蛋白可成功用于女性生殖系统几种恶性和良性肿瘤的闪烁扫描检测。肿瘤聚集可能是由于负责炎症和免疫反应的特定细胞（如巨噬细胞和淋巴细胞）的激活。
