Gitau R, Adams D, Fisk N M, Glover V
Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK.
Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F166-9. doi: 10.1136/adc.2004.049320.
Fetal exposure to testosterone has been implicated in programming childhood behaviour, but little is known about the determinants of fetal testosterone concentrations.
To investigate the relation between fetal testosterone and maternal and fetal cortisol.
Clinically indicated blood samples taken from 44 human fetuses (mean gestational age 27 weeks, range 15-38), together with paired maternal samples, were analysed for testosterone and cortisol concentrations.
Male fetuses had significantly higher concentrations of testosterone than females. Female but not male fetal concentrations rose significantly with gestational age. Fetal testosterone correlated positively with both fetal cortisol and maternal testosterone concentrations. Multiple regression showed that maternal testosterone and fetal cortisol were independently correlated with fetal plasma testosterone in both sexes.
Unlike the norm in the adult, where testosterone production is often inhibited by cortisol, in the fetus there is a positive link between the two.
胎儿暴露于睾酮与儿童期行为编程有关，但关于胎儿睾酮浓度的决定因素知之甚少。
研究胎儿睾酮与母体及胎儿皮质醇之间的关系。
对从44例人类胎儿（平均孕周27周，范围15 - 38周）采集的临床指征血液样本以及配对的母体样本进行睾酮和皮质醇浓度分析。
男性胎儿的睾酮浓度显著高于女性。女性胎儿而非男性胎儿的睾酮浓度随孕周显著升高。胎儿睾酮与胎儿皮质醇及母体睾酮浓度均呈正相关。多元回归分析显示，母体睾酮和胎儿皮质醇在两性中均与胎儿血浆睾酮独立相关。
与成年人的情况不同，在成年人中睾酮生成常受皮质醇抑制，而在胎儿中二者存在正向联系。
