Tenditnik M V, Shurlygina A V, Mel'nikova E V, Kudriavtseva N N, Trufakin V A
Ross Fiziol Zh Im I M Sechenova. 2004 Dec;90(12):1522-9.
Subpopulation spectrum of T lymphocytes (CD3+, CD4+, CD8+, CD25+, and CD3(+)25+) in thymus, spleen and inguinal lymphatic nodes have been studied in male mice after 20 days of psychoemotional stress produced by social defeats in daily agonistic confrontations. A reduction of total number of cells, of absolute numbers of all researched subpopulations of lymphocytes and % CD3+ cells in thymus of submissive mice was shown in comparison with intact animals. Reduction of total number of splenocytes and absolute numbers of CD4+ and CD8+ lymphocytes has been observed in a spleen of submissive mice. Besides, % CD3+, CD25+, CD4+ and CD25+ cells were increased in these animals in comparison with intact mice. The absolute number of cells with CD8 phenotype was increased in inguinal lymphatic nodes. The data obtained suggest that the chronic psychoemotional stress is accompanied by serious changes of the cellular link of immunity. The effect of chronic emotional social stress on mutual interaction of the central and peripheral links of immunity has been discussed.
在每日对抗性冲突中遭受社会挫败所产生的心理情绪应激20天后，对雄性小鼠胸腺、脾脏和腹股沟淋巴结中T淋巴细胞（CD3+、CD4+、CD8+、CD25+和CD3(+)25+）的亚群谱进行了研究。与未受影响的动物相比，受攻击的小鼠胸腺中细胞总数、所有研究的淋巴细胞亚群的绝对数量以及CD3+细胞百分比均有所减少。在受攻击的小鼠脾脏中，观察到脾细胞总数以及CD4+和CD8+淋巴细胞的绝对数量减少。此外，与未受影响的小鼠相比，这些动物中CD3+、CD25+、CD4+和CD25+细胞的百分比增加。腹股沟淋巴结中具有CD8表型的细胞绝对数量增加。所获得的数据表明，慢性心理情绪应激伴随着免疫细胞环节的严重变化。文中还讨论了慢性情绪性社会应激对免疫中枢和外周环节相互作用的影响。
