Involvement of presynaptic 5-HT(1A) receptors in immunomodulation in conditions of psychoemotional tension.

The development of an immune reaction in CBA mice during activation and blockade of serotonin 1A (5-HT(1A)) autoreceptors with highly selective agents has characteristic features depending on the behavioral stereotype formed. The 5-HT(1A) receptor agonist 8-OH-DPAT (0.1 mg/kg 15 min before immunization) did not alter the number of IgM antibody-forming cells in the spleen at the peak of the immune reaction (day 4) in aggressive mice, but increased the number in submissive mice, in which the immune response without treatment was lower than that in aggressive animals. Blockade of the same receptor type with WAY-100635 (0.1 mg/kg 30 min before immunization) led to a decrease in the immune response in animals with aggressive behavior and an increase in submissive animals. The question of the influences of agents acting on presynaptic 5-HT(1A) somatodendritic autoreceptors on the immune response, depending on the functional state of 5-HT(1A) receptors and the balance of activities in the serotoninergic and dopaminergic systems as a whole, is discussed.