Al-Daraji W I, Al-Dawoud A
Department of Histopathology, East Lancashire Hospitals NHS Trust, Burnley BB10 2PQ, UK.
Clin Exp Dermatol. 2005 Mar;30(2):137-40. doi: 10.1111/j.1365-2230.2004.01667.x.
A 75-year-old woman presented to her general practitioner with a keratotic skin lesion on her abdomen. Microscopic examination showed an irritated seborrheic keratosis. However, further inspection revealed a well-defined dome-shaped area in the dermis showing a number of small nerve fibres admixed with relatively few mature ganglion cells. Both the spindle cell component and the ganglion cells stained positively for S-100 protein, neurofilament protein and CD56 (Leu-19, NCAM) by routine immunohistochemistry. Primary cutaneous ganglioneuroma is an exceedingly rare benign tumour of the skin with only 13 cases having been reported in English literature. We describe the second case of primary cutaneous ganglioneuroma associated with seborrheic keratosis.
一名75岁女性因腹部出现角化性皮肤病变就诊于她的全科医生。显微镜检查显示为刺激性脂溢性角化病。然而，进一步检查发现真皮内有一个边界清晰的圆顶状区域，可见一些小神经纤维与相对较少的成熟神经节细胞混合存在。通过常规免疫组织化学检测，梭形细胞成分和神经节细胞的S-100蛋白、神经丝蛋白和CD56（Leu-19，神经细胞黏附分子）均呈阳性染色。原发性皮肤神经节神经瘤是一种极其罕见的皮肤良性肿瘤，英文文献中仅报道过13例。我们描述了第二例与脂溢性角化病相关的原发性皮肤神经节神经瘤病例。
