Obert P, Mandigout S, Vinet A, Nottin S, N'Guyen L D, Lecoq A M
Laboratoire de Physiologie des Adaptations Cardiovasculaires à l'Exercice, Faculté des Sciences, Département STAPS, 33 rue Louis Pasteur, 84000 Avignon, France.
Int J Sports Med. 2005 Mar;26(2):122-7. doi: 10.1055/s-2004-817857.
Little attention has been paid to children with respect to factors controlling maximal oxygen uptake (V.O (2max)). This study was therefore specifically designed to examine the potential relationships between cardiac size, diastolic function and O (2) carrying capacity with maximal aerobic capacity. Specifically, body size indices (body surface area, lean body mass), resting left ventricular dimensions and filling characteristics, blood haemoglobin concentration as well as V.O (2max) established during a maximal cycle exercise test were assessed in a large cohort (n = 142) of healthy 10 - 11 year old boys and girls. Results were compared between groups of low (< 50, L), moderate (50 - 60, M) and high (> 60, H) V.O (2max) (ml . min (-1) . kg (-1) of lean body mass). Moreover, potential contributors to V.O (2max) variance were investigated using univariate and multivariate regression analyses over the overall population. The major results show no differences between the 3 groups for all diastolic and systolic function indices as well as blood haemoglobin and systemic vascular resistances (used as an index of afterload). None of these variables emerged from regression analyses as potential predictors of V.O (2max.) After accounting for body size variation, heart dimensions, and especially left ventricular internal dimensions, differed between H and M and L and were associated with higher cardiac filling and subsequently stroke volume. Strong relationships between V.O (2max) and heart dimensions were noticed, due primarily but not exclusively to the influence of body size. After adjusting for lean body mass, end-diastolic diameter contributed modestly (8 %) but significantly to V.O (2max) variance, which is biologically meaningful.
在控制最大摄氧量（V.O₂max）的因素方面，儿童很少受到关注。因此，本研究专门设计用于检查心脏大小、舒张功能和氧携带能力与最大有氧能力之间的潜在关系。具体而言，在一大群（n = 142）健康的10 - 11岁男孩和女孩中，评估了体型指数（体表面积、瘦体重）、静息左心室尺寸和充盈特征、血红蛋白浓度以及在最大周期运动试验中确定的V.O₂max。比较了低（< 50，L）、中（50 - 60，M）和高（> 60，H）V.O₂max（每千克瘦体重每分钟毫升数）组之间的结果。此外，使用单变量和多变量回归分析对总体人群研究了V.O₂max方差的潜在影响因素。主要结果显示，三组在所有舒张和收缩功能指标以及血红蛋白和体循环血管阻力（用作后负荷指标）方面均无差异。在回归分析中，这些变量均未作为V.O₂max的潜在预测因子出现。在考虑体型变化后，心脏尺寸，尤其是左心室内径，在高分组与中分组以及低分组之间存在差异，并且与更高的心脏充盈和随后的每搏输出量相关。注意到V.O₂max与心脏尺寸之间存在密切关系，这主要但并非唯一地归因于体型的影响。在调整瘦体重后，舒张末期直径对V.O₂max方差的贡献适度（8%）但显著，这具有生物学意义。
