Butcher G A
Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ.
Parasitology. 2005 Feb;130(Pt 2):141-50. doi: 10.1017/s003118200400650x.
Although early reports on HIV and malaria in co-infected subjects indicated little apparent interaction between the two infections, more recent investigations have found evidence for HIV increasing the risk from malaria. Conversely, increased viral load in susceptible cells occurs in malaria-infected people. However, the overall pattern of results is still somewhat confusing and contradictory. While morbidity from malaria may be greater in HIV-positive patients and in several reports the mortality risk is also higher, major increases in blood-stage parasitaemias that one might expect are not generally observed. The results of surveys are summarized and discussed in the context of what is known of malaria and HIV immunology in the light of recent data from humans as well as animal models.
尽管早期关于合并感染HIV和疟疾患者的报告表明这两种感染之间几乎没有明显相互作用，但最近的调查发现有证据显示HIV会增加患疟疾的风险。相反，疟疾感染者体内易感细胞中的病毒载量会增加。然而，总体结果模式仍有些令人困惑且相互矛盾。虽然HIV阳性患者患疟疾的发病率可能更高，且在一些报告中死亡风险也更高，但人们通常并未观察到预期中血液阶段疟原虫血症的大幅增加。根据来自人类以及动物模型的最新数据，结合已知的疟疾和HIV免疫学知识，对各项调查结果进行了总结和讨论。
