Vanage G R, Garde S V, Sheth A R, Gopalkrishnan K
Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
Int J Androl. 1992 Apr;15(2):114-26. doi: 10.1111/j.1365-2605.1992.tb01120.x.
Passive immunization of adult male hamsters for 12 weeks against peptide (As-PIP), a sperm coating antigen, resulted in selective elevation of the blood levels of FSH, impairment of spermatogenesis, and complete infertility when males were mated with normal cycling females. Passive immunization of male marmosets with As-PIP for 8 weeks was also effective and was reversible, without causing any obvious change in mating behaviour. These preliminary studies in hamsters and marmosets indicate that antibodies to a prostatic 'inhibin' peptide represent a promising new approach to male contraception.
成年雄性仓鼠被动免疫针对精子包被抗原肽（As-PIP）12周，当这些雄性仓鼠与正常发情周期的雌性仓鼠交配时，导致促卵泡激素（FSH）血液水平选择性升高、精子发生受损以及完全不育。用As-PIP对雄性狨猴进行8周的被动免疫也有效且具有可逆性，不会引起交配行为的任何明显变化。这些在仓鼠和狨猴身上的初步研究表明，针对前列腺“抑制素”肽的抗体代表了一种有前景的男性避孕新方法。
